Vitamin D sufficiency may reduce MI, all-cause mortality ris
Treating to a vitamin D level of at least 30 ng/mL is associated with significantly lower risk for myocardial infarction and all-cause mortality among adults with no prior MI history, according to an analysis of Veterans Affairs data.

The aim of the study was to examine the effects of the vitamin D (Vit-D) treatment and nontreatment on Vit-D–deficient patients without a prior history of myocardial infarction (MI).

This was a retrospective, observational, nested case–control study of patients (N?=?20 025) with low 25-hydroxyvitamin D ([25-OH]D) levels (less than 20 ng/mL) who received care at the Veterans Health Administration from 1999 to 2018. Patients were divided into 3 groups: Group A (untreated, levels less than 20 ng/mL), Group B (treated, levels 21-29 ng/mL), and Group C (treated, levels more than 30 ng/mL). The risk of MI and all-cause mortality were compared utilizing propensity score–weighted Cox proportional hazard models.

-- Among the cohort of 20 025 patients, the risk of MI was significantly lower in Group C than in Group B and Group A.

-- There was no difference in the risk of MI between Group B and Group A.

-- Compared with Group A, both Group B and Group C had significantly lower all-cause mortality.

-- There was no difference in all-cause mortality between Group B and Group C.

Conclusively, in patients with Vit-D deficiency and no prior history of MI, treatment to the (25-OH)D level of more than 20 ng/mL and more than 30 ng/mL was associated with a significantly lower risk of all-cause mortality. The lower risk of MI was observed only in individuals maintaining (25-OH)D levels more than 30 ng/mL.