Vitamin D supplementation in Prediabetes patients lowers typ
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The effect of vitamin D supplementation on the risk of type 2 diabetes mellitus (T2DM) remains controversial because most randomized controlled trials (RCTs) have been small or have reported low doses of vitamin D.

This study aimed to conduct a meta-analysis of RCTs testing vitamin D supplementation in the prevention of T2DM. It included RCTs that reported the effect of vitamin D supplementation for at least 1 year on T2DM prevention. Primary outcome of the meta-analysis was the incidence of T2DM.

Nine RCTs were included (43559 participants). The mean age was 63.5 years. The risk ratios (RR) for vitamin D compared with placebo was 0.96. In trials testing moderate to high doses of supplementation (greater than 1000 IU/day), all conducted among participants with prediabetes, the RR for vitamin D compared with placebo was 0.88. In contrast, the trials testing lower doses, which were conducted in general population samples, showed no risk reduction.

Conclusively, In patients with prediabetes, vitamin D supplementation at moderate to high doses, significantly reduced the incidence risk of T2DM, compared with placebo.

Source: https://academic.oup.com/jcem/article-abstract/105/8/dgaa335/5850844?redirectedFrom=fulltext
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