Week-by-week alcohol consumption during the 1st trimester in
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Half of the women use alcohol in the first weeks of gestation, but most stop once pregnancy is detected. The relationship between the timing of alcohol use cessation in early pregnancy and spontaneous abortion risk has not been determined. Findings from a recent study suggested that each additional week of alcohol exposure during the first trimester increases the risk of spontaneous abortion, even at low levels of consumption and when excluding binge drinking.

This study aimed to evaluate the association between week-by-week alcohol consumption in early pregnancy and spontaneous abortion. Among 5353 participants, 49.7% reported using alcohol during early pregnancy and 12.0% miscarried. Median gestational age at the change in alcohol use was 29 days (interquartile range, 15–35 days). Alcohol use during weeks 5 through 10 from the last menstrual period was associated with increased spontaneous abortion risk, with risk peaking for use in week 9. Each successive week of alcohol use was associated with an 8% increase in spontaneous abortion relative to those who did not drink. This risk is cumulative. In addition, the risk was not related to a number of drinks per week, beverage type, or binge drinking.

Source:https://www.ajog.org/article/S0002-9378(20)30725-0/fulltext
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