What Is The Impact of Antibiotics On Gut Microbiome & Resist
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Healthcare-associated infections with antibiotic-resistant pathogens are increasing worldwide, posing a serious threat to our healthcare system. According to current estimates, up to ten million fatal cases are expected to be caused by antibiotic-resistant pathogens in 2050. A major target for these investigations is the human gut because its microbiome is a well-known reservoir for a vast number of antibiotic resistance genes (ARGs).

During a Recent Study, comparision was done between ciprofloxacin & cotrimoxazole. While both antibiotics had a similar negative impact on gut microbiome diversity, there were significant differences in resistome alterations under treatment. In terms of resistome alterations, researchers discovered a complex interplay between the antibiotics with concomitant treatment, the clinical status of a patient, and the baseline status of the gut microbiome, resistome, and plasmidome.

Researchers have stressed upon the contributing effect of virostatic agents. It has recently been reported that an unexpectedly high number of drugs affect microbiota, even those without a direct antimicrobial activity like proton pump inhibitors, antidiabetics, psychotropic drugs, and many more.

It was found that baseline laboratory parameters like creatinine and bilirubin were further independent contributors, probably due to their importance for the pharmacokinetics of drugs or due to the interplay between liver metabolism and the gut microbiome . For instance, increasing serum levels of creatinine shifted the resistome always in the same direction as cotrimoxazole in the study, probably due to the renal excretion of both drug’s components and their accumulation under reduced kidney function resulting in a prolonged effect. Underlying hematological diseases were also identified as other important cofactors.

Source: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-019-0692-y
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