What Studies Show About Pregnancy, COVID-19 Vaccines
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A recent data review by the Advisory Committee on Immunization Practices shows that over 30,000 women who are pregnant have been safely vaccinated for COVID-19. The preliminary safety study, which took place between December 2020 and January 2021, compared women who were pregnant and not pregnant, and who received the Pfizer or Moderna COVID-19 vaccines.

They found that one day after vaccination, local reactions in both study groups were similar. In nearly all cases, no significant differences in reactions were experienced, such as localized pain, redness, fatigue, headache or fever. Women who are pregnant and participate in V-Safe, a safety monitoring program following COVID-19 vaccination are being followed at these intervals to monitor for longer-term adverse effects:

- Once per trimester.
- After delivery.
- When the infant is 3 months old.

Approximately 2,000 pregnant patients have been enrolled in the V-Safe monitoring program and nearly 300 of those patients have completed pregnancies to date. Pregnancy outcomes, such as miscarriage, stillbirth, pregnancy complications and infant outcomes, among participants are no different than general rates in women who are pregnant and have not been vaccinated for COVID-19.

Pregnant women are at increased risk for bad outcomes when they get COVID-19, says Doctor. Any severe illness in pregnancy increases the risk to the outcome of the pregnancy. Despite the lack of controlled trials in pregnant women, experts still encourage them to be vaccinated. Researchers are determining if pregnant women who are vaccinated for COVID-19 can transfer immunity to their unborn babies.

There are some early signs from studies that have been conducted that are small, that show those antibodies do get transferred across the placenta to the baby. Pfizer is enrolling about 4,000 women in a large study, looking at the immunity that babies get when they're too young to be vaccinated. Could they still get enough benefit from their mother being vaccinated to protect them from COVID-19 in infancy? It's still a question that's being answered, and there's some very promising early results.