What is the association between left atrial appendage (LAA)
Out of 10,633 adults who underwent coronary artery bypass grafting (CABG) and/or valve surgery between January 2000 and December 2005, 9,792 patients with complete baseline characteristics, surgery procedure, and follow-up data were included in this analysis. A propensity-score matching analysis based on 28 pretreatment covariates was performed, and 461 matching pairs were derived and analyzed to estimate the association of LAA closure with early POAF (AF ?30 days of surgery), ischemic stroke, and mortality.

In the propensity-matched cohort, the overall incidence of POAF was 53.9%. In this group, the rate of early POAF among the patients who underwent LAA closure was 68.6% versus 31.9% for those who did not undergo the procedure (p < 0.001). LAA closure was independently associated with an increased risk of early POAF (adjusted odds ratio [95% confidence interval (CI)], 3.88 [2.89-5.20]), but did not significantly influence the risk of stroke (adjusted hazard ratio [95% CI], 1.07 [0.72-1.58]) or mortality (adjusted hazard ratio [95% CI], 0.92 [0.75-1.13])....