White matter hyperintensities increase long-term risk for is
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
White matter hyperintensity volume, type and shape correlated with an increased risk for mortality and ischemic stroke among patients with manifest arterial disease, according to findings from the SMART-MR study published in Neurology.

This study aimed to determine whether white matter hyperintensity (WMH) markers on MRI are associated with long-term risk of mortality and ischemic stroke.

Researchers included consecutive patients with manifest arterial disease enrolled in the SMART-MR study. They obtained WMH markers (volume, type and shape) from brain MRI scans performed at baseline using an automated algorithm. During follow-up, occurrence of death and ischemic stroke was recorded. Using Cox regression, we investigated associations of WMH markers with risk of mortality and ischemic stroke, adjusting for demographics, cardiovascular risk factors and cerebrovascular disease.

Results:
-- Researchers included 999 patients (59 ± 10 years; 79% male) with a median follow-up of 12.5 years (range 0.2–16.0 years).

-- A greater periventricular or confluent WMH volume was independently associated with a greater risk of vascular death for a 1 unit increase in natural log-transformed WMH volume) and ischemic stroke.

-- A confluent WMH type was independently associated with a greater risk of vascular and nonvascular death, and ischemic stroke.

-- A more irregular shape of periventricular or confluent WMH, as expressed by an increase in concavity index, was independently associated with a greater risk of vascular and nonvascular death, and ischemic stroke.

Conclusively, WMH volume, type and shape are associated with long-term risk of mortality and ischemic stroke in patients with manifest arterial disease.

Source: https://n.neurology.org/content/early/2021/03/16/WNL.0000000000011827
Like
Comment
Share