Whole Grains Beneficial For Cholesterol Control, Finds Study
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Observational data have established a link between the consumption of whole grains and reduced risk of cardiovascular disease (CVD); however, there is a need to review interventional research.

This study aimed to determine whether interventions providing whole grain or whole pseudo-grain for dietary consumption improved CVD-related outcomes compared with refined grain or placebo in adults with or without chronic disease and/or associated risk factors.

A systematic review and meta-analysis of randomized controlled trials that compared whole-grain vs refined-grain or placebo consumption by human adults was conducted. Data were extracted for 14 types of CVD risk factors (40 outcomes in total). Twenty-five randomized controlled trials were included and 22 were meta-analyzed. Interventions ranged from 2 to 16 weeks; most samples were healthy (n = 13 studies) and used mixed whole grains (n = 11 studies).

The Meta-analysis found that whole-grain oats improved total cholesterol and low-density lipoprotein cholesterol, whole-grain rice improved triglycerides, and whole grains (all types) improved hemoglobin A1c and C-reactive protein.

Conclusively, for adults with or without CVD risk factors, consuming whole grains as opposed to refined grains can improve total cholesterol, low-density lipoprotein cholesterol, hemoglobin A1c, and C-reactive protein.

There is insufficient evidence to recommend the whole grains as opposed to refined grains for the prevention and treatment of CVD. Further interventional research is needed to better understand the preventive and treatment potential of whole-grain and whole pseudo-grain dietary intake for cardiovascular disease, particularly among those with existing CVD risk factors.

Source: https://jandonline.org/article/S2212-2672(20)30650-X/fulltext
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