Whole blood exchange could offer disease-modifying therapy f
Alzheimer’s disease (AD) is the major form of dementia in the elderly population. This study describes that the development of cerebral amyloid plaques in a transgenic mice model of AD (Tg2576) was significantly reduced by 40–80% by exchanging whole blood with normal blood from wild-type mice having the same genetic background. Importantly, such reduction resulted in an improvement in spatial memory performance in aged Tg2576 mice. The exact mechanism by which blood exchange reduces amyloid pathology and improves memory is presently unknown, but measurements of A in plasma soon after blood exchange suggest that mobilization of A from the brain to blood may be implicated. Our results suggest that a target for AD therapy may exist in the peripheral circulation, which could open a novel disease-modifying intervention for AD.

Source: https://www.nature.com/articles/s41380-022-01679-4