Whom should we screen for Cushing’s syndrome?
Cushing’s syndrome (CS) is a rare and serious disease with high mortality. Patients are often diagnosed late in the course of the disease. Of 377 patients referred for 18 key symptoms, of which five were more common in patients with CS than in those where CS was ruled out: Osteoporosis (8% vs. 2%, p = 0.02), adrenal incidentaloma (17% vs. 8%, p = 0.01), metabolic syndrome (11% vs. 4%, p = 0.02), myopathy (10% vs. 2%, p <0.001) and presence of multiple symptoms (16% vs. 1%, p < 0.001). Obesity was more common in patients where CS was ruled out (30% vs. 4%, p <0.001), but recent weight gain was prominent in those with CS. 68 of 93 patients with CS (73%) had typical chief complaints, as did 106 of 284 of patients with rule-out CS status (37%).

Source: https://academic.oup.com/jcem/advance-article/doi/10.1210/clinem/dgac379/6612816?rss=1
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