Why COVID-19 May Be Less Common in Children Than Adults ?
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Lower levels of ACE2 nasal gene expression in children may explain why children have a lower risk of Covid-19 infection and mortality, suggests the study published in the JAMA journal. The SARS-CoV-2 virus uses ACE2 to enter the host. ACE2 nasal gene expression could potentially be used as a biomarker to evaluate Covid-19 susceptibility.

Results: ACE2 gene expression in the nasal epithelium, the first point of contact for SARS-CoV-2 and the human body, was lowest in younger children and increased with age.

How: A retrospective analysis of 305 patients aged 4 to 60 years encountered within the Mount Sinai Health System in New York.

Study Conclusions: These findings could help explain why children appear to be less susceptible to Covid-19 infection. The results may point to a potential biomarker of Covid-19 susceptibility. Prospective studies are needed to assess the degree to which ACE2 expression can be used as a biomarker for COVID-19 susceptibility.

Note: This article is brief compilation. The complete study is attached as pdf.

Source: https://www.eurekalert.org/pub_releases/2020-05/tmsh-msr052120.php
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