Wolman Disease
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A 1-month-old female presented to our institution with a history of poor feeding, diarrhea, and a 2-lb weight loss. Upon evaluation, the patient was determined to have severe dehydration, acute renal failure, and metabolic acidosis. Cornelia De Lange syndrome was initially suspected by the geneticists due to dysmorphic facial features, including prominent eyebrows, thin upper lip, and smooth philtrum. Imaging revealed bilateral adrenal enlargement and calcifications with the maintenance of the adreniform shape. Bone marrow findings and genetic tests were performed and confirmed the diagnosis - Wolman disease. The differential diagnoses include neuroblastoma, ganglioneuroblastoma, adrenal hemorrhage, granulomatous disease/infection, lymphoma, and adrenal carcinoma.

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