Women experiences higher Axial Spondyloarthritis disease bur
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In the US-based Corrona Psoriatic Arthritis/Spondyloarthritis (PsA/SpA) Registry, researchers compared patient characteristics and disease burden between men and women with axial spondyloarthritis (axSpA) which concluded that women had a larger overall illness load.

Patients aged more than 18 years with axSpA enrolled in the Corrona PsA/SpA Registry who were not concurrently diagnosed with PsA were included. Patient demographics, clinical characteristics, disease activity, patient-reported symptoms, work productivity, and treatment history at enrollment were compared between men and women using t tests or Wilcoxon rank-sum tests for continuous variables and ?2 or Fisher’s exact tests for categorical variables.

--Of 498 patients with axSpA and available sex information, 307 were men and 191 were women.

--Compared with men, women had higher disease activity as measured by Bath Ankylosing Spondylitis Disease Activity Index, Bath Ankylosing Spondylitis Functional Index, and physician global assessment, and had higher tender/swollen joint counts and enthesitis scores.

--Women also had worse patient-reported symptoms (pain, fatigue, HAQ-S, and EQ-VAS), greater work and activity impairment, and were less likely to work full time than men.

--Prior csDMARD and prednisone use was more common in women than in men. Additionally, women were more likely to have diagnoses of depression and fibromyalgia.

Women had a larger overall illness load and more peripheral signs than males, in conclusion. Improved awareness of sex differences in the presentation of axSpA should help clinicians detect the disease earlier and manage it better.

Source: https://www.jrheum.org/content/early/2021/04/10/jrheum.201549