Worst Outcomes observed with Alcohol withdrawal in patients
Alcohol withdrawal (AW) syndrome is an independent risk factor for postoperative complications. This study aims to evaluate the influence of AW on perioperative outcomes in patients who underwent primary total knee (TKA) or total hip arthroplasty (THA).

Patients undergoing TKA/THA were identified. The primary exposure of interest was AW. Multivariable adjusted models were used to evaluate the association of AW with in-hospital medical complications, surgical complications, mortality, cost and length of stay (LOS) in patients undergoing TKA/THA.

Results:
--There were 2,971,539 adult hospitalizations for THA and 6,367,713 hospitalizations for TKA included in the present study, among which 0.14% of AW for THA patients and 0.10% of AW for TKA patients.

--Multivariable adjustment analysis suggested that AW was associated with an increased risk of medical complications (OR=2.08), surgical complications (OR=1.75) and had 4.79 times increase of in-hospital mortality, 26% increase of total cost and 53% increase of LOS in THA procedures.

--For TKA procedures, AW was also associated with increased risk of medical complications (OR=3.14), surgical complications (OR=2.07) and 4.24 times increase of in-hospital mortality, 29% increase of total cost and 58% increase of LOS after multivariable adjustment.

AW is linked to a higher risk of in-hospital mortality, as well as medical and surgical problems. Proactive AW surveillance and management could help patients with THA and TKA procedures have better results.

Source: https://www.sciencedirect.com/science/article/abs/pii/S0883540321006343?dgcid=rss_sd_all
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