Yale researchers discover how tick-borne bacteria cause infe
Before infecting humans, tick-borne bacteria or viruses first have to get past a tick's defenses to colonize it. How this occurs is not well understood. To investigate, Yale researchers studied a model of the second-most-common tick-borne infection in the United States, human granulocytic anaplasmosis, which can cause headaches, muscle pain, and even death.

The researchers found that in ticks, the bacterium that causes the infection, A. phagocytophilum, triggers the expression of a particular protein. This protein alters molecules in the tick's gut, allowing the bacteria to enter and colonize the gut microbes.

"It's like a stealth warrior that indirectly changes the tick by using the tick's own defense system," said Erol Fikrig, M.D., chief of the Infectious Diseases Section at Yale School of Medicine and senior author of the study....

http://www.news-medical.net/news/20170117/Yale-researchers-discover-how-tick-borne-bacteria-cause-infection.aspx
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