Yellow papules and nodules in an infant: Case report
Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...Now open: Certificate Course in Management of Covid-19 by Govt. Of Gujarat and PlexusMDKnow more...
An 11-month-old infant presented with asymptomatic yellow reddish monomorphic papules and nodules on the skin of the face, ears, truncus, and upper extremities, slowly increasing in number in the last six months. Few lesions had already undergone a spontaneous regression without scarring. No systemic or mucosal involvement has been noticed. A normal mental and physical development of the child was present. Punch biopsy was taken from a 7-month-old lesion. Staining with CD68 and S100 was performed.

The most likely diagnosis was Benign cephalic histiocytosis. It is a rare non-Langerhans cell histiocytosis. This patient corresponds to all four diagnostic criteria:
(1) onset of disease within the first 3 years of life;
(2) location of skin lesions on the scalp and lack of lesions on the hands, feet, mucous membranes, and internal organ involvement;
(3) spontaneous complete remission of symptoms;
(4) monomorphic infiltration of histiocytes that do not express S100 and CD1a.

The typical histology is diffuse infiltrate of histiocytes, mainly in the upper dermis or could be lichenoid-like close under the epidermis. The cells have oval or reniform vesicular nucleus and ill-defined pale cytoplasm. Grouped lymphocytes and occasional eosinophils could be seen. Xanthomatisation can be seen in lesions of long duration. The histiocytes in BCH express typical non- Langerhans markers including CD68, factor XIIIa, CD16, but S100 is negative.

Source: https://www.jaadcasereports.org/article/S2352-5126(20)30879-1/fulltext?rss=yes
Like
Comment
Share