Younger Age of T1D Dx Tied to Higher Mortality Risk: LANCET
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Earlier age at onset of type 1 diabetes is associated with increased risks for mortality and cardiovascular disease, particularly among women, a Lancet study suggests.

Using national Swedish registries, researchers matched 27,000 adults with type 1 diabetes (mean age, 29) to 135,000 population-based controls without diabetes. During a median 10 years' follow-up, 3.5% of the diabetes cohort died, versus 1.1% of controls.

Patients with diabetes had increased risks for nearly all outcomes studied - including all-cause mortality, cardiovascular mortality, cardiovascular disease, and coronary heart disease — and risks increased as age at diabetes diagnosis decreased. In particular, men diagnosed before age 10 lost 14 life-years and women lost 18 life-years, while those diagnosed at age 26–30 lost 9 and 10 life-years, respectively.

The researchers write, "Our data suggest a need to better target cardiovascular risk in those with childhood-onset type 1 diabetes." They call for a "greater consideration of statins once individuals with early-onset type 1 diabetes reach 30–40 years of age."