Zoledronic acid provides protection against bone loss after
An annual infusion of zoledronic acid can help attenuate bone loss in adults with acute spinal cord injury, according to a study published in the Journal of Bone and Mineral Research.

Researchers conducted a single-center, randomized, double-blind, placebo-controlled trial of adults aged 18 years or older with acute spinal cord injury. Participants had a spinal cord injury within 120 days of enrollment, were unable to ambulate independently, and had no known endocrinopathies other than diabetes and treated thyroid conditions. Laboratory values, a physical examination and medical history were obtained at baseline. Participants were randomly assigned to a zoledronic acid infusion or placebo at baseline. After 1 year, participants were randomly assigned within their own group again to zoledronic acid or placebo, creating four treatment groups: zoledronic acid both years, zoledronic acid at baseline only, zoledronic acid in year 2 only, and placebo in both years. DXA imaging, CT imaging and bone metabolism biomarkers were measured every 6 months.

Zoledronic acid attenuates BMD losses after 1 year
There were 60 participants included in the study, with 30 in the zoledronic acid group and 30 receiving placebo at baseline. There were 10 people who received zoledronic acid both years who completed the trial at month 24, 14 who received zoledronic acid only after the first year, 12 who received zoledronic acid in year 2 only, and 13 who received placebo both years.

In year 1, adults receiving placebo lost 12.8% areal bone mineral density at the total hip and 11.3% at the femoral neck. Those receiving zoledronic acid lost 2.2% areal BMD at the total hip and 1.7% at the femoral neck. The placebo group had an areal BMD decrease of 2.3% at the spine, whereas the zoledronic acid group had a 2.7% areal BMD gain. At the femur, those receiving zoledronic acid also attenuated losses in epiphyseal integral bone mineral content, integral BMD, trabecular bone mineral content, cortical bone mineral content, cortical bone volume, torsional strength index and metaphyseal integral bone mineral content.

Similar benefits with one infusion vs. two

After 2 years, participants only receiving placebo had a 21.8% areal BMD decrease in the total hip and 16.8% decrease in the femoral neck. Adults who received zoledronic acid both years lost 0.6% in total hip areal BMD and 1.4% in femoral neck areal BMD. Participants who received zoledronic acid at baseline only also attenuated BMD losses, with a 6% decrease in areal BMD at the total hip and 3.2% loss at the femoral neck. Those who received zoledronic acid only in year 2 lost 9.98% of areal BMD in the total hip and 8.27% in the femoral neck. All three groups who received at least one dose of zoledronic acid also had significant improvements in spine areal BMD compared with those receiving placebo only.

“Because this was the longest trial to date, no one had ever looked at two annual (zoledronic acid) infusions in the spinal cord injury population,” researchers said. “We were able to examine this question, but with a reduced sample size because of our study design. Ultimately, we did expect to see some benefit from two annual infusions. We saw some moderate effects at 24 months between one infusion vs. two annual infusions, but these were not statistically significant.”

There were no differences in CT measures at the femur at 24 months for any group, but the placebo-only group had greater losses in epiphyseal cortical bone mineral content and cortical bone volume at 24 months compared with the group receiving zoledronic acid both years. No unanticipated safety outcomes occurred during the trial.

Researchers said the benefits of one infusion of zoledronic acid were “quite convincing” and said another trial is needed in the future to more closely examine whether there is an additional benefit for having two annual infusions vs. one.

Source: https://asbmr.onlinelibrary.wiley.com/doi/abs/10.1002/jbmr.4416
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