Adolescents With Obesity Risk Developing T1D in Adulthood
Adolescents with overweight or obese had a higher risk of developing type 1 diabetes (T1D) in young adulthood, authors of a large retrospective cohort study reported. In an analysis that included more than 1.4 million individuals ages 16-19 followed for a median of 11 years, those classified as having obesity were twice as likely to develop type 1 diabetes as those with optimal weight (HR 2.05, 95% CI 1.58-2.66). Adolescents with overweight had a 54% risk increase (HR 1.54, 95% CI 1.23-1.94) of T1D. Furthermore, individuals with a higher BMI in the normal range (75th to 84th percentiles) also had an elevated risk (HR 1.41, 95% CI 1.11-1.78). For each one-increment increase in BMI standard deviation, T1D risk increased by 25% (HR 1.25, 95% CI 1.17-1.32),