Association between risk of VTE and mortality in patients wi
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VTE risk was related with the 30-day mortality risk in COVID-19 patients. Higher score of Padua, IMPROVE or Caprini RAM means higher mortality risk. Incremental increases in VTE risk were associated with higher SOFA score. VTE RAMs indicate higher accuracy to predict 30-day mortality in these patients

This study aimed to investigate the association between risk of VTE with 30-day mortality in COVID-19 patients.

1030 COVID-19 patients were retrospective collected, with baseline data on demographics, Sequential Organ Failure Assessment (SOFA) score, and VTE risk assessment models (RAMs) including Padua Prediction Score (PPS), International Medical Prevention Registry (IMPROVE) and Caprini RAM.

-- Thirty-day mortality increased progressively from 2% in patients at low risk of VTE to 63% in those at high risk defined by PPS.

-- Similar findings were also observed by IMPROVE and Caprini score.

-- Progressive increases in VTE risk also were associated with higher SOFA score.

-- The presence of high risk of VTE was independently associated with mortality regardless of adjusted gender, smoking status and some comorbidities with hazard ratios of 29.19, 37.37, 20.60 for PPS, IMPROVE and Caprini RAM, respectively.

-- Predictive accuracy of PPS (Area Under Curve, AUC, 0.900), IMPROVE (AUC, 0.917) or Caprini RAM (AUC, 0.861) as the risk of mortality was markedly well.

Conclusively, this study firstly investigate that the presence of high risk of VTE identifies a group of COVID-19 patients at higher risk for mortality. Furthermore, there is higher accuracy of VTE RAMs to predict mortality in these patients.

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