Blood fat levels predict diabetes remission following gastri
Obesity is a prevalent health threat and risk factor for type 2 diabetes. Researchers analyzed blood samples from 1,156 individuals, ages 18-72, collected over a 12-year span. The subjects were divided into three groups: 418 people who underwent gastric bypass surgery; 417 who did not have surgery because they were denied insurance coverage; and 321 severely obese individuals who didn't consider the surgery. The researchers chose to have two control groups to account for the possibility that those who were denied insurance coverage were more motivated to diet, exercise, and engage in other weight-loss strategies than those who had no interest in gastric bypass

Overall, the scientists found that low ceramide levels prior to gastric bypass surgery predicted which patients would achieve remission of the diabetes two years later. Of the 67 gastric bypass patients who had diabetes prior to surgery, 49 (73%) either had transient or sustained remission of their type 2 diabetes. However, those individuals with high ceramides did not achieve diabetes remission, regardless of weight change.

A newly developed test could help doctors more accurately predict whether individuals who undergo gastric bypass surgery will experience a remission of type 2 diabetes within two years of the procedure.