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Sep 4, 2018
Can I get any info about the mechanism of RB gene of a tumor?
Dr. P●●●●i C●●●●●●l
Rb Gene or Retinoblastoma Gene belongs to the family of "Tumor Suppressor Genes" , the Rb Gene codes for the retinoblastinoma protien or pRb which is responsible for halting the cell cycle until the cell is deemed fit to divide. So in short it prevents excessive and/or defective cell multiplication. In carcinogenesis, the Rb gene dysfunctions (mutation) that leads to an unchecked progression of
cell cycle. For detailed understanding you can refer to a. Robbin' s pathology b. Harsh Mohan pathology textbook (star with this, the concept is explained here in a very simple way)
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Sep 6, 2018