Determining the optimal time interval between Vaginal Dinopr
Vaginal dinoprostone 12 hours before office hysteroscopy (OH) was more effective than vaginal dinoprostone administrated 3 hours before OH says a recent study published in The Journal of Minimally Invasive Gynecology.

The aim was to determine the optimal timing of vaginal dinoprostone administration before office hysteroscopy (OH) in nulliparous women.

180 nulliparous women undergoing diagnostic OH were enrolled. Researchers randomly allocated women to long-interval or short-interval dinoprostone groups where 3 mg dinoprostone was administered vaginally 12 hours before OH in the long-interval group or 3 hours before OH in the short-interval group.

The primary outcome was pain during OH measured by a 100-mm visual analog scale. Secondary outcomes were ease of hysteroscope passage, women satisfaction score, drug side effects.

- Long-interval dinoprostone had lower pain scores during OH. Contrarily, pain scores 30 minutes postprocedure were similar in both groups.

- Women were more satisfied, and clinicians found hysteroscope passage through the cervical canal easier and shorter in the long-interval dinoprostone group than the short-interval group. Side effects were comparable in both study groups.

In particular, Vaginal dinoprostone 12 hours before OH was more effective than vaginal dinoprostone administrated 3 hours before OH in reducing pain during OH in nulliparous patients with easier hysteroscope insertion, shorter procedure duration, and better women satisfaction score.

Source: https://doi.org/10.1016/j.jmig.2021.06.021
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