DNA from Stone Age ‘chewing gum’ tells an incredible story
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She lived on an island in the Baltic Sea around 3,700 B.C. She was lactose intolerant and may have suffered from gum disease, and she had recently dined on a meal that included ducks and hazelnuts. Like many ancient European hunter-gatherers, she was likely blue-eyed with dark skin and hair.

What we can’t know about the individual researchers call Lola, however, is how long she lived—or even when or where she died—because all that’s known about Lola comes from DNA captured in a small wad of tree pitch that she chewed on and spat out some 5,700 years ago.

This unique genetic snapshot in history is revealed in a study published today in Nature Communications, marking the first time researchers have been able to reconstruct a complete human genome from the deep past via “non-human material” rather than from physical remains.

In addition to Lola’s genetic story, the international team of researchers was also able to identify the DNA of plants and animals she had likely recently consumed, as well as the DNA of the countless microbes that lived inside her mouth—collectively known as her oral microbiome.

“This is the first time we have the complete ancient human genome from anything other than human bone, and that in itself is quite remarkable,” says Hannes Schroeder, an associate professor of evolutionary genomics at the University of Copenhagen’s Globe Institute and a co-author of the study. “What’s so exciting about this material is that you can also get microbial DNA.”

While our scientific understanding of the human microbiome is still in its very early stages, researchers are beginning to understand what an important role it plays in our health. Variations in our microbiome may impact everything from susceptibility to infection and heart disease to even possibly behavior.

By being able to sequence ancient DNA together with the individual’s microbiome, Schroeder says, researchers will be able to understand how the human microbiome has evolved over time—revealing, for instance, how the dietary shift from hunting and gathering to agriculture thousands of years ago may have altered our microbiome for better or worse.

Read more: https://www.nationalgeographic.com/history/2019/12/dna-stone-age-chewing-gum-microbiome-story/
H●●●●i K●●●●a and 31 others like this15 shares
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Dr. V●●●j S●●●●●a
Dr. V●●●j S●●●●●a Pharmacology
The gut starts from the mouth so it is not surprising that from chewing gum one could do this. When we were being developed embryologically, one tube formed the entire CVS, the other tube formed the entire CNS and the third tube developed into the gut and its appendages and liver and is as important as the other two tubes. The glucose sensor is in the duodenum and not just glucokinase in the beta cell of the islets of Langerhans. Then we have the gut flora and microbiome, the enteric nervous system (vagus in particular) and the enteric endocrine system (incretin axis), which is the biggest endocrine organ in the body. Then of course the twin cycle hypothesis of the liver and pancreas (counterpoint study).... Read more
Dec 19, 2019Like4
A●●●T P●●●●●R
A●●●T P●●●●●R General Medicine
It' s like Evolutionary concept of human nutrition with biological mechanism body place...like Mediterranean diet that only depndS on Green leaves, Vegetables and Meats hunting ... They had everyday struggle to reach there food on time . what genomics research showed by International Research Team.
Dec 19, 2019Like