Eruptive pseudoangiomatosis - cherry angiomas with perilesio
Eruptive pseudoangiomatosis (EP) is a rare viral exanthem characterized by acute onset of hemangiomata like lesions, however, histological findings are distinct from that of true angiomas. A case series of 12 cases of Eruptive pseudoangiomatosis have been reported in the Indian Journal of Dermatology, Venereology and Leprology.

The lesions were moderately pruritic papules with a characteristic perilesional halo, distributed mainly on extremities, face, neck and trunk. Six of 12 patients, including two children, had reduced total leucocyte count and 9 had lymphocytosis. Other routine laboratory tests like liver function tests, renal function tests, blood sugar levels, and urine complete examination were normal. Histopathology of the lesions revealed normal epidermis with mild perivascular lymphohistiocytic infiltrate in the papillary dermis and dilated capillaries with prominent, plump endothelial cell lining.

EP is a rarely reported entity, and the precise cause of the vascular changes is still unclear. Previous studies have suggested it to be a “dermal hypersensitivity reaction” to viral infection or a direct viral effect on the vascular endothelium. EP is a rare disease characterized by initial prodrome of mild fever, sore throat, or gastrointestinal symptoms, followed by the appearance of hemangiomata like cutaneous lesions, resolving in a few days. The etiology of this eruption is still unknown. Association with insect bites, infection with ECHO virus E25 and E32, coxsackie B, Epstein Barr virus, and cytomegalovirus have been described in patients in whom eruption occurred after prodromal symptoms.

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