Exposure To Common Cold Virus Can Protect Against COVID-19 I
Get authentic, real-time news that helps you fight COVID-19 better.
Install PlexusMD App for doctors. It's free.
In a new study, the researchers found that the common respiratory virus jump-starts the activity of interferon-stimulated genes, early-response molecules in the immune system which can halt replication of the SARS-CoV-2 virus within airway tissues infected with the cold.

Triggering these defenses early in the course of COVID-19 infection holds promise to prevent or treat the infection, said Ellen Foxman, assistant professor of laboratory medicine and immunobiology at the Yale School of Medicine and senior author of the study. One way to do this is by treating patients with interferons, an immune system protein which is also available as a drug.

For the study, her team infected lab-grown human airway tissue with SARS-CoV-2 and found that for the first three days, viral load in the tissue doubled about every six hours. However, replication of the COVID-19 virus was completely stopped in tissue which had been exposed to rhinovirus. If antiviral defenses were blocked, the SARS-CoV-2 could replicate in airway tissue previously exposed to rhinovirus.

Researchers found evidence of rapid growth of SARS-CoV-2 in the first few days of infection, followed by activation of the body's defenses. The same defenses slowed down SARS virus infection even without rhinovirus, but only if the infectious dose was low. This suggests that the viral load at the time of exposure makes a difference in whether the body can fight the infection.

The virus COVID-19 grows rapidly for the first few days of infection, before host defenses kick in. Interferon treatment holds promise but it could be tricky because it would be mostly effective in the days immediately after infection, when many people exhibit no symptoms. In theory, interferon could be used prophylactically in people at high risk who have been in close contact with others diagnosed with the virus.

Source:
https://apps.crossref.org/pendingpub/pendingpub.html?doi=10.1084/jem.20210583
Dr. T●●●●z H●●●●●●i and 8 others like this8 shares
Like
Comment
Share