First trimester dexamethasone treatment is not associated wi
Prenatal treatment with dexamethasone (DEX) has been used to prevent virilization in females at risk of congenital adrenal hyperplasia (CAH). Both affected and unaffected girls, as well as boys, are treated until the genotype and sex of the fetus are known (gestational week 10-12). After that only affected girls are treated until term. 18 participants (8 females), at risk of having CAH, exposed to DEX treatment, and 38 controls (24 females), age range 16 -26 years, from a single research institute, underwent functional magnetic resonance imaging of the brain during rest. We used two different approaches: an exploratory whole-brain analysis and seed-based analysis. For seed-based analysis, we chose 3 different brain regions (amygdala, hippocampus, and superior frontal gyrus) based on our previous findings and literature evidence.