Hydrocephalus: new complication of congenital zika syndrome
Hydrocephalus may be a complication of congenital Zika syndrome, and the presenting signs and symptoms are challenging to recognize, a recently published case series in JAMA Neurology suggests.

Hydrocephalus is a treatable but potentially fatal complication that has not been previously described in congenial Zika syndrome (CZS).

This case series describes 24 patients who developed hydrocephalus between 3 and 18 months of age and had at least 1 test positive for anti-Zika antibodies, including 14 who had symptoms and signs suggestive of hydrocephalus, 18 who had cerebellar or brainstem hypoplasia at baseline, and 2 who had no such symptoms but were found to have reduced brain volume on repeated imaging; at a second computed tomographic scan, all showed marked increases of ventricular volume and reduction of brain tissue.

This study provides evidence that hydrocephalus is a complication of CZS in at least a proportion of patients. The clinical spectrum of this condition continues to evolve, but given that presenting signs and symptoms of hydrocephalus can be challenging to recognize in CZS, the authors provisionally recommend that high suspicion and appropriate monitoring for hydrocephalus should be part of the standard care of patients with CZS.

Read in detail here: https://jamanetwork.com/journals/jamaneurology/fullarticle/2714718