Identifying Novel Correlates of Acute Calcium Pyrophosphate
A Study was conducted to investigate previously identified and novel correlates of acute calcium pyrophosphate (CPP) crystal arthritis among well-characterized cases.

Researchers identified cases of acute CPP crystal arthritis using a validated algorithm applied in the Partners HealthCare electronic health record (EHR). Cases were matched to general patient controls on year of 1st EHR encounter and index date.

Researchers identified 1697 cases matched to 6503 controls. 56.7% were female, 80.8% White, 10.3% Black.

--All pre-specified covariates were more common in cases than controls.

--Osteoarthritis, male sex, rheumatoid arthritis, gout, proton pump inhibitors, loop diuretics, and thiazides were significantly associated with acute CPP crystal arthritis after full adjustment.

--Black race was associated with lower odds for acute CPP crystal arthritis compared to White race.

Conclusively, Using a validated algorithm to identify nearly 1700 patients with acute CPP crystal arthritis, researchers confirmed important correlates of this acute manifestation of CPPD. This is the first study to report higher odds for acute CPP crystal arthritis among males.