Impact of compliance among patients with Diabetic Macular Oe
This study aimed to compare the anatomical and functional outcomes between patients with non-proliferative diabetic retinopathy (NPDR) with diabetic macular oedema (DME) who adhered to intravitreal aflibercept therapy and patients lost to follow-up (LTFU).

200 patients were enrolled and the interval between each procedure and the subsequent follow-up visit was recorded . Moreover, visual acuity (VA) and anatomical outcomes were measured at each follow-up examination.

--Among the patients, 103 patients adhered to intravitreal aflibercept therapy and follow-up examination while 97 patients were LTFU.

--46 patients LTFU who returned for further treatment showed a significant decrease in VA from 0.51 to 0.89 logarithm of the minimum angle of resolution (logMAR) after 48 months.

--Compared with the adherent group, the return group showed a worse VA at 48 months.

--Further, 1 patient in the adherent group and 8 patients in the return group developed a proliferative DR.

--Patients who were LTFU had a 13.0 times greater chance to develop a proliferative DR.

In conclusion, the results were markedly worse compared to patients with good adherence to DME after intravitreal aflibercept therapy. In addition, the probability for developing proliferative DR in LTFU patients was 13 times higher. Considering the possible advancement of the disease, effective techniques for optimizing the functional output of people at risk of decreased adhesion should be adopted.