Impaired Blood Sugar Levels In Type 2 Diabetes Tied To Poor
This study aimed to investigate the association between glycated hemoglobin (HbA1c) and myocardial dysfunction and to determine whether its association is independent of myocardial perfusion.

Sixty-four patients with type 2 diabetes mellitus (T2DM) were recruited. They were divided into groups according to their HbA1c level: the controlled T2DM group (HbA1c less than 7%) and uncontrolled T2DM groups (HbA1c more than 7%). Meanwhile, 30 age-matched healthy volunteers were included. All patients with T2DM and healthy controls underwent cardiovascular magnetic resonance imaging to evaluate the myocardial mechanics and perfusion parameters.

-- The circumferential and longitudinal peak strain (PS) and global radial, circumferential, and longitudinal peak strain diastolic strain rates (PDSRs) were lower in the uncontrolled T2DM group than in the controls without diabetes.

-- In multivariable linear regression analysis, HbA1c was independently related to all directions of the PS and PDSR.

-- The myocardial perfusion parameters were not independently associated with the PS or PDSR.

Conclusively, cardiac function is impaired in Chinese T2DM patients with poor glucose control (HbA1c more than 7%), with preserved left ventricular (LV) ejection fraction, and disease duration less than 10 years. Poor blood glucose control is an independent predictor of LV myocardial dysfunction for patients with short-term T2DM.