Infertility history linked with increased risk of heart fail
Infertility affects about 1 in 5 US women and includes a spectrum of conception difficulties, but its link with heart failure has not been well-studied until recently. Researchers studied postmenopausal women from the Women's Health Initiative (WHI) and examined whether infertility was associated with development of heart failure.

There are two types of heart failure: heart failure with preserved ejection fraction (HFpEF) and heart failure with reduced ejection fraction (HFrEF). Ejection fraction is a measurement related to the volume percentage of blood that is pumped from the left ventricle of the heart during each beat. An ejection fraction less than 50% is commonly viewed as abnormal or reduced.

The team found an association between infertility and overall heart failure, specifically with HFpEF, a form of heart failure that is far more common in women regardless of fertility history. Among the 38,528 postmenopausal women studied, 14% of the participants reported a history of infertility. Over a 15-year follow up period, the researchers noted that infertility was associated with 16% future risk of overall heart failure. When they examined heart failure subtypes, they found that infertility was associated with a 27% increased future risk of HFpEF.

Women who had experienced infertility had a 16% increased risk of heart failure compared with women who did not have an infertility history.

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