Malaria elimination: Vaccines should be tested on larger gro
To find an effective vaccine against malaria it is crucial to test candidate vaccines on larger groups of people than previously thought - according to a new study published in PLOS Computational Biology. The researchers from Erasmus MC Rotterdam and Radboud University Medical Center Nijmegen developed a mathematical model to determine the minimum number of people required for a good vaccine trial.

Malaria continues to be a major public health challenge; killing 438,000 people every year and being the leading cause of death in children worldwide. Before a malaria vaccine may be tested on a large group of people, there must be sufficient evidence for a relevant and beneficial effect, with minimal risks and side effects. Few candidate vaccines meet these requirements....