Mixing BP Meds With NSAID May Be 'Triple Whammy' for Kidneys
Patients who mix a diuretic and renin-angiotensin system (RAS) inhibitor with a nonsteroidal anti-inflammatory drug (NSAID) could face a higher risk of developing acute kidney injury (AKI). The study also looked at risk factors associated with the effect of triple therapy with these agents, which has been called "triple whammy" AKI.

Researchers identified dehydration and high sensitivity to drug treatment as key contributing factors to the development of triple whammy AKI. Their model simulations suggested that low water intake, the myogenic response (that is, the reflex response of arteries and arterioles to changes in blood pressure to maintain consistent blood flow), and drug sensitivity "may predispose patients with hypertension to develop triple whammy-induced AKI,

In an earlier study, triple therapy with a diuretic, RAS inhibitor, and NSAID was associated with a 31% increased risk for AKI, relative to diuretic and RAS inhibitor therapy only.

Source: https://www.medscape.com/viewarticle/973885?src=rss