Non-thyroidal illness syndrome -associated multi-organ dysfu
The purpose of this cohort study was to investigate the relationship between non-thyroidal illness syndrome (NTIS) and severe multi-organ dysfunction, measured by Sequential Organ Failure Assessment (SOFA) score more than 11, after surgical repair of type A aortic dissection (TAAD).

This observational study included 310 patients with TAAD surgically repaired between January 2019 and December 2020 in Beijing Anzhen Hospital.

Among a total of 310 patients with TAAD undergoing surgical repair included in this study, 132 (42.6%) experienced surgery-associated NTIS. Severe multi-organ dysfunction was experienced more often in patients with NTIS (27.3% vs 11.2%). Multivariable analysis demonstrated NTIS was closely associated with an increased risk of severe multi-organ dysfunction (OR?=?2.54), which predicted an in-hospital death rate of 95%.

NTIS was also related with in-hospital major adverse cardiovascular and cerebral events (MACCEs) (, acute kidney injury (AKI), postoperative pulmonary complications (PPCs). However, hepatic inadequacy was comparable in the NTIS and control groups.

Conclusively, NTIS was closely associated with multi-organ dysfunction after surgical repair of TAAD, which may be further correlated with an increased incidence of in-hospital mortality and complications.