Osteoarthritis is associated with an increased risk of Parki
A Study was conducted to investigate whether patients with osteoarthritis (OA) are at a higher risk of developing Parkinson's disease (PD).

33,360 patients who were 50-64 years old and had OA were enrolled in the OA group. The comparison group consisted of 33,360 age- and sex-matched, randomly sampled subjects without OA. Then, their PD-free survival curves were generated using the Kaplan-Meier method. Multivariable Cox proportional-hazard regression analysis was employed to estimate the effect of having OA on patients subsequent risk of PD.

Results:
--Of the two groups, the OA group had a significantly higher risk of developing PD (adjusted hazard ratio [aHR]=1.41).

--The PD-free survival rate of the OA group was also significantly lower than that of the comparison group.

--The subgroup analysis showed that patients with knee or hip OA appeared to have a higher magnitude of PD risk (aHR 1.55) than patients with non-knee and non-hip OA (aHR 1.42) or with uncategorized OA (aHR 1.32).

Conclusively, these findings suggest that OA is linked to an increased risk of developing PD.

Source: https://onlinelibrary.wiley.com/doi/10.1002/acr.24708?af=R
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