PDE5 Inhibitors and Nitrates in Men With Ischemic Heart Dise
#The American Heart Association recommends that PDE5 inhibitors should not be given with nitrates, and nitrates can only be taken safely at least 24 and 48 hours after use of fast- and slow-acting PDE5 inhibitors, respectively.

#A observational study using prescription data from a large US-wide electronic health record database, the 3,167 patients with access to prescription co-possession of PDE5 inhibitors and nitrates had no increase in rate of hypotensive/CV outcomes relative to those using prescription nitrates alone (with or without erectile dysfunction). In this study, only 27% of the 252 patients with adequate documentation were warned of co-administration at the time of co-prescription.

#The data accumulating suggests that the use of PDE5 inhibitors may reduce CV event rates in IHD.

Source: https://www.acc.org/Latest-in-Cardiology/Journal-Scans/2022/04/27/18/47/Adverse-Events-Associated-With-Coprescription