Premenstrual dysphoric disorder: Study links severe PMS to c
A landmark study by US-based National Institutes of Health (NIH) researchers has established the biological cause for why women get irritable, sad and even suicidal during the days leading up to their menstrual period. Premenstrual dysphoric disorder (PMDD) is a mood disorder that affects 2-5% of women of reproductive age. It is a much severe form of premenstrual syndrome (PMS). The symptoms are so severe that they can actually stop women from living their regular life.

Researchers have shown that women with PMDD are more sensitive to the change of sex hormones — estrogen and progesterone — during their menstrual cycle. They found that turning off estrogen and progesterone eliminated PMDD symptoms, while re-introducing the hormones triggered the re-emergence of symptoms. Hence, PMDD is a disorder of cellular response to estrogen and progesterone.