Risk Factors for Development of Keratoconus, Study finds
This study aimed to analyze associations between several hereditary and environmental predictors and the development of keratoconus.

Patients with keratoconus and their age- and gender-matched controls were asked about childhood and early teenage eye rubbing, ocular trauma, obesity, contact lens wear, smoking and sunlight exposure, family history of keratoconus, parental consanguinity and information related to socio-economic status.

--A total of 166 individuals were included. On univariable analysis, eye rubbing, family history of keratoconus and parental consanguinity were significant risk factors for keratoconus, whereas all other factors were non-significant.

--On multivariable analysis, eye rubbing, family history of keratoconus and parental consanguinity, again, emerged as significant risk factors for disease development.

Finally, a family history of keratoconus, eye rubbing, and paternal consanguinity were all found to be significant risk factors for the development of keratoconus. These findings back with the theory of multiple etiology, with inherited predisposition being the most essential factor.

Source: https://www.dovepress.com/risk-factors-for-development-of-keratoconus-a-matched-pair-case-contro-peer-reviewed-fulltext-article-OPTH