Serum calponin 2 is a novel biomarker of tubal ectopic pregn
Serum protein calponin 2 (CNN2) is a helpful biomarker for tubal ectopic pregnancy (EP), finds a recent study Fertility and Sterility.

The aim was to evaluate serum protein calponin 2 (CNN2) as a candidate biomarker for tubal ectopic pregnancy (EP).

Serum samples were obtained from 84 patients with EP, 39 with viable intrauterine pregnancy (vIUP), and 42 with miscarriage. Moreover, 10 fallopian tube and corresponding villous tissue samples from patients with EP, 6 villous tissue samples from patients with vIUP, and 10 villous tissue samples from patients with miscarriage were collected.

- CNN2 was highly expressed in villous stromal cells isolated from patients with EP, and CNN2 messenger ribonucleic acid expression was upregulated in villous tissues from women with EP compared with that in women with vIUPs and miscarriages.

- Serum CNN2 concentration was higher in women with EP than that in women with vIUP and miscarriage.

- The serum CNN2 predicted EP from vIUP and miscarriage with areas under the curve of 0.931.

- For discriminating EP from miscarriage only, the AUC was 0.906. In contrast, the AUCs for serum human chorionic gonadotropin were 0.809 and 0.637, respectively.

In conclusion, the data highlight the possibility of serum CNN2 as a single biomarker for the diagnosis of EP.

Source: https://doi.org/10.1016/j.fertnstert.2021.05.101
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