Study describes Retinal Structure - Function Correlation in
A Study was conducted to examine the relationship of visual function as assessed by visual acuity, contrast sensitivity, and multifocal electroretinography (mfERG) to macular structural and microvascular measures on optical coherence tomography (OCT) and angiography (OCTA) in individuals with diabetes.

Right eyes of 121 adults with type 2 diabetes with no diabetic retinopathy (DR), mild or moderate nonproliferative DR (NPDR) were examined. Participants underwent assessment of glycated haemoglobin (HbA1C), blood pressure, best corrected visual acuity (LogMAR), contrast sensitivity (CS), mfERG, ultrawide field fundus photography, OCT and OCTA. Correlations were assessed by Spearman’s rank correlation (rho).

--Of the total of 121 eyes, 89 had No DR, 32 had mild to moderate NPDR.

--In the No DR group, the LogMAR acuity was significantly and negatively correlated to central subfoveal thickness (CST), macular vessel density and perfusion.

--Contrast sensitivity correlated to foveal avascular zone circularity; mfERG P1 response densities were better with higher macular perfusion index.

--In the NPDR group, the LogMAR acuity also showed a significant negative correlation to CST. Other correlations were not significant.

Conclusively, retinal and visual functional abnormalities are seen in diabetic patients with no DR, and these changes are linked to subclinical retinal structural changes that can be detected by multimodal imaging.