Study finds, Birth Characteristics Among Children Diagnosed
A Study was conducted to evaluate whether children with neurofibromatosis type 1 (NF1) and tuberous sclerosis have different birth characteristics compared with the general population.

Researchers identified all individuals for whom information on both biological parents was available (n=4 242 122). NF1 and TS patients were identified using data from Swedish population-based health data registers. Researchers assessed using logistic regression models the association between these neurocutaneous syndromes and birth characteristics in a cohort that included 1804 NF1 and 450 TS patients.

--Children with NF1 and TS were significantly more likely to be born preterm and via a caesarean section.

--In addition, children with NF1 were also more likely to be born with other birth characteristics, such as short length, a large head circumference, and a low Apgar score.

--Moreover, children with NF1 had an increased odds of being born with a high birth weight or large for gestational age.

In conclusion, children with NF1 and TS differ from the general population in terms of numerous birth features, with the highest connections identified in individuals with NF1 for high birth weight and being large for gestational age.