Study Finds, Long-term Visual Outcomes in Eyes with Diabetic
A Study was conducted to analyze the morphological characteristics and long-term visual outcomes in eyes with diabetic retinopathy (DR) and diabetic macular edema (DME) treated with anti-vascular endothelial growth factor (VEGF) therapy.

Subjects with a long-term follow-up and evidence of resolved DME in at least one visit after 5 years of follow-up following the initiation of anti-VEGF therapy were included. At the study visit, structural OCT scans were reviewed for qualitative features reflecting a distress of the neuroretina or retinal pigment epithelium (RPE).

--61 eyes were included and divided into two subgroups according to the visual acuity (VA) at the study visit.

--The external limiting membrane (ELM) and RPE bands were more frequently disrupted/absent in the “poor/intermediate vision” group.

--Similarly, disorganization of retinal inner layers (DRIL) was more prevalent in the “poor/intermediate vision” group.

--The foveal and parafoveal outer retinal thicknesses were reduced in poor/intermediate vision eyes.

--Multivariate stepwise linear regression analysis demonstrated that VA was associated with appearances of the RPE and ELM, foveal and parafoveal outer retinal thicknesses.

Conclusively, OCT indicators of long-term visual outcomes in eyes with DME treated with anti-VEGF include changes in the outer retina and RPE.