Study finds, Ocular characteristics and complications in pat
The inherited heterogeneous connective tissue disorder osteogenesis imperfecta (OI) is characterized by bone fragility, low bone mineral density, skeletal deformity, and blue sclera. Mutations in the COL1A1 or COL1A2 genes are the most common cause of dominantly inherited forms of OI. Changes in collagen type I have an effect on a number of structural components of the eye.

Collagen type I is one of the major structural proteins of the eyes and therefore is the eye theoretically prone to alterations in OI. The aim of this systematic review was to provide an overview of the known ocular problems reported in OI.

--The results of this current review show that almost every component of the eye could be affected in OI.

--Decreased thickness of the cornea and sclera is an important factor causing eye problems in patients with OI such as blue sclera.

--Findings that stand out are ruptures, lacerations and other eye problems that occur after minor trauma, as well as complications from standard surgical procedures.

Multiple structural components of the eye are affected by changes in collagen type I. Patients with OI should wear safety glasses to avoid unintended eye damage. Furthermore, surgery should be treated with caution when it is needed.