Study finds, Outcomes of Microbial Keratitis Cases Resistant
The purpose of this study was to describe demographics, predisposing factors, clinical features, treatment, and outcomes of microbial keratitis cases resistant to antimicrobials.

A retrospective case series was conducted. All patients with microbial keratitis resistant to antimicrobials who underwent a corneal scrape and culture were included. Coagulase-negative staphylococci (CoNS), Staphylococcus aureus (S. aureus), and Corynebacterium spp. resistant to cefalotin, chloramphenicol, ciprofloxacin, or gentamicin were analyzed.

--115 episodes had a resistant CoNS, 24 S. aureus, and 12 Corynebacterium spp.

--Antimicrobial resistance was associated with older women with Corynebacterium spp., corneal graft, and previous topical steroid use.

--Larger epithelial defects and infiltrates were more likely to be associated with Corynebacterium spp., but not statistically significant.

--At the initial and final visits, resistant S. aureus and Corynebacterium spp. cases were more likely to be classified as blind compared with CoNS.

--Corneal perforation occurred more often in resistant S. aureus cases, whereas slow and nonhealing epithelial defects needing other procedures were more likely to occur with resistant Corynebacterium spp.

Patients with resistant CoNS, in particular, were younger, had smaller ulcers, and had mild vision loss. The visual and clinical outcomes of resistant CoNS were much better than those of resistant S. aureus or Corynebacterium spp.