Study finds, Predictors of Peripapillary and Macular Optical
The signal intensity has a major impact on the vessel density and perfusion density produced by optical microangiography. The effects of gender, hypertension, diabetes, and axial length on these measurements were not statistically significant.

A Study was conducted to assess the effect of subject-related factors (age, gender, systemic hypertension, diabetes and axial length) and machine related factor (signal strength) on vessel density (VD) and perfusion density (PD) generated by optical microangiography (OMAG) in peripapillary and macular regions.

In an observational, cross-sectional study of 200 eyes of 100 healthy people, mean and sectoral VD and PD were assessed on disc and macular scans (ages 18-80). The influence of subject- and machine-related variables on VD and PD parameters was assessed using multivariate mixed effect models.

Results:
--Mean (±standard deviation) peripapillary and macular VD of the study population was 18.56±1.11 mm-1 and 20.59±1.85 mm-1 respectively.

--Mean peripapillary and macular PD was 46.43±3.22% and 37.61±3.26% respectively.

--Sex, hypertension, diabetes and axial length did not have any statistically significant effect on the OMAG measurements.

--However, the signal strength (SS) had significant effect on the OMAG measurements. Mean peripapillary and macular VD on scans with SS of 10 was 1.4 mm-1 and 3.79 mm-1 greater respectively than that on scans with SS of 7.

--Mean peripapillary and macular PD on scans with SS of 10 was 4.43% and 7.85% greater respectively than that on scans with SS of 7.

Finally, even when the scans had appropriate signal strength as recommended by the manufacturer, there is a significant correlation between the scan's SS and the optical coherence tomography angiography (OCT-A) measurements generated by OMAG (more than 7). When interpreting OCT-A measurements, this must be taken into account.

Source: https://journals.lww.com/glaucomajournal/Abstract/9000/Predictors_of_Peripapillary_and_Macular_Optical.97585.aspx
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