Study: Lower Cognitive Function in Patients with Functionall
The aim of this study was to determine whether functional and structural glaucoma damage is associated with cognitive function.

This was a cross-sectional analysis comprising 172 patients with glaucoma with a mean age of 70.6 years. Functional glaucoma severity was evaluated according to the visual field mean deviation, and structural glaucoma severity was determined based on circumpapillary retinal nerve fiber layer (RNFL) thickness. The main outcome measure was cognitive impairment defined by a mini-mental state examination (MMSE) score of less than 26 and MMSE-blind score of more than 16.

--The prevalence of patients with cognitive impairment was significantly higher in the severe glaucoma group than in the mild glaucoma group.

--Similar results were obtained in the analyses with MMSE-blind score of less than 16.

--Multivariable logistic regression analysis adjusted for potential confounders, including age, body mass index, education, visual acuity, hypertension, diabetes, and depressive symptoms, indicated a higher odds ratio for cognitive impairment in patients with severe glaucoma than in those with mild glaucoma and in relation to a 10-microm thinning of the RNFL.

In a glaucoma cohort, functional and structural glaucoma damage were both associated with worse cognitive performance, regardless of age or visual acuity.