Study paves the way for better understanding how prostate ca
Scientists have taken a major leap forward in being able to fully understand how prostate cancer cells acquire their ability to spread from the initial tumour to other areas of the body.The Nottingham Trent University study is significant because metastasis - when cells begin to invade other sites such as the bone or brain - is responsible for the vast majority of prostate cancer-related deaths.

For the first time, a team at the university has been able to generate a panel of prostate cancer cells in the laboratory which spontaneously undergo a process thought to be involved in the spread of disease.

The work is expected to provide vital insight into the biology and spread of aggressive prostate cancers and help to improve the management, treatment and survival of patients with therapy-resistant disease.Cells can acquire the invasive and migratory properties needed for metastasis by reactivating a programme called 'epithelial-to-mesenchymal transition' (EMT).