Sugar variability may predict liver cancer risk in diabetic
Although diabetes is a well-known risk factor for hepatocellular carcinoma (HCC), exactly which metabolic parameters of diabetes are associated with HCC remains unexplored. This study investigated the relationship between glucose variability (GV) and HCC in diabetic patients through a nationwide population-based study.

A population-based cohort study including 674,178 diabetic subjects participating in more than 3 health examinations within 5 years from the index year (2009-2010) were followed until the end of 2017.

-- During a median follow-up of 6.7 years, there were 5,494 cases of HCC.

-- When classified groups according to glucose level, the highest risk for HCC was observed when the basal blood glucose level was 180 mg/dL or greater.

-- Researchers observed increasing trends for the relationship between GV and HCC in multivariable Cox proportional analyses.

-- The risk of HCC increased by 27% for the highest quartile of GV relative to the lowest quartile.

-- These findings were consistent regardless of the presence of chronic viral hepatitis or cirrhosis, alcohol consumption, or body mass index.

GV is an independent predictor of HCC, even after adjusting for confounding factors. There was a linear relationship between increase in GV and prevalence of HCC. Visit-to-visit GV might be helpful for identifying diabetic patients at high risk of HCC.