The relationship between central obesity and bone mineral de
The relationship between obesity and osteoporosis is an important public health issue. Researchers conducted a two-sample Mendelian randomization analysis. Genomewide significant single nucleotide polymorphisms associated with waist circumference, hip circumference, waist-to-hip ratio, waist circumference adjusted by body mass index (WCadjBMI), hip circumference adjusted by BMI (HCadjBMI) and waist-to-hip ratio adjusted by BMI (WHRadjBMI) were obtained from a large-scale database containing 224,459 samples. The BMD summary dataset was obtained from a UK Biobank database including 265,627 participants.

The results provided strong evidence that the HCadjBMI trait was causally and negatively associated with BMD (: 0.135, 95% CI 0.216 to 0.054; P=0.001), while the WHR trait was causally and positively associated with BMD (: 0.194, 95% CI 0.062 to 0.325, P=0.004). No significant effects were observed for other traits on BMD. This study indicates variations in the abilities of different central obesity traits to influence BMD.